2020-01-31
A short-course RT regimen of 25 Gy in 5 fractions is an acceptable treatment option for patients aged ≥65 years, mainly those with a poor performance status or contraindication to chemotherapy, which would be indicated in cases of methylated O6 methylguanine-DNA-methyltransferase promoter tumors.
The trial included newly diagnosed glioblastoma aged 65 years or older and patients aged 50 years or older with a Karnofsky performance score (KPS) of 50–70. With 98 patients enrolled, there were no reported differences in OS between the two groups: the 25 Gy cohort had a median OS of 7.9 months and the 40 Gy 2020-01-31 More recently, Roa et al. investigated short-course radiation therapy (40 Gy in 15 fractions) compared to ultra-hypofractionated radiation therapy (25 Gy in 5 fractions) in elderly/frail patients with glioblastoma. 2021-02-18 PATIENTS AND METHODS: Patients older than 65 years with GBM, who underwent surgical resection/biopsy and treated with short-course radiotherapy or concurrent chemo-radiation therapy, were evaluated.
21 Cells were resuspended in fresh culture medium (DME, 25% FCS, 20 mM In particular after high doses of γ-irradiation (2 and 3 Gy, respectively), it was sometimes iv) Rat glioma cells : Rat C6 glioma cells were obtained from the European Of these, 9-HODE and 5-HETE at 24 h survived the 10% false discovery rate cutoff as art enhanced solubility of carbohydrate and protein fractions of the samples in CH2Cl2) in the lattice or collection of data at very low temperature (25 vs. progression of glioblastoma under therapy-an exploratory analysis of AVAglio There are five research groups; three from the Department of Endocrine Oncology. and two from the Quantification of normal cell fraction and copy. number Characterization of an imatinib-sensitive glioblastoma. subset. 25.
RT (60 Gy/30 fractions ing tumor with a 1.5 cm margin. An isotropic expansion of 3 mm was added to the CTV 50 and CTV 60 to generate the planning target volume (PTV) 50 and PTV 60 respectively.
2017-06-10
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2017-12-01
A planning study by Chang et al. 59 was conducted in 48 patients comparing this approach with that of the RTOG 97‐10 trial.
59 was conducted in 48 patients comparing this approach with that of the RTOG 97‐10 trial. between the two treatment regimens in elderly and/or frail patients with glioblastoma multiforme while demonstrating no increase in toxicity for a shorter fractionated regimen (25 Gy in 5 daily fractions) and similar quality of life between the two regimens. 2017-01-01
REVIEW ARTICLE The evolving roles and controversies of radiotherapy in the treatment of glioblastoma Eric Hau, FRANZCR,1,2 Han Shen, BMed, MMSc, PhD,3 Catherine Clark, FRANZCR,2 Peter H. Graham, FRANZCR,4 Eng-Siew Koh, FRANZCR, 5,6 & Kerrie L. McDonald, PhD1 1Cure Brain Cancer Foundation Biomarkers and Translational Research Laboratory, Prince of Wales Clinical School, UNSW, Sydney, …
with fraction sizes ranging from 2.4 Gy to 7.25 Gy with Two important aspects of the fractionation scheme and external beam radiotherapy and #9.5 Gy with high-dose- technique need to be discussed.
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Histol Histopathol. 2020 Feb 5:18207.
2020-11-09 · A total dose of 20 Gy was prescribed to the PTV Flair (99% isodose line covering 99% of the PTV), 25 Gy was prescribed to the PTV-boost in 5 daily fractions at the isodose of 67% (i.e. maximum
2021-02-18 · In a small retrospective study comparing hypofractionated SRT (25 Gy in 5-Gy fractions) plus bevacizumab or the alkylating agent fotemustine, median survival times and 12-month survival rates were 11 months and 30% for patients treated with SRT and bevacizumab and 8.3 months and 5% for those treated with SRT and fotemustine (p = 0.01); respective median progression-free survival times were 6 and 4 months (p = 0.01). 2019-06-06 · A phase III trial conducted by Roa and colleagues compared two different hypofractionation schemes (40 G y in 15 fractions and 25 Gy in 5 fractions) without concurrent TMZ in patients ≥ 65 years of age with KPS >50 .
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A total dose of 20 Gy was prescribed to the Flair (fluid-attenuated inversion recovery) planning tumor volume (PTV) and 25 Gy to the PTV-boost (T1 MRI contrast enhanced area) in 5 daily fractions to the isodose of 67% (maximum dose within the PTV-boost was 37.5 Gy).
Shepherd et al. reported hypofractionated stereotactic radiotherapy in treatment of Treatment consisted of a total dose of 25 Gy in five daily fractions (dose/fraction 5.00 Gy) over 1 week in arm 1 and 40.05 Gy in 15 daily fractions (dose/fraction 2.67 Gy) over 3 weeks in arm 2. Verification of all treatment fields on the first day of treatment was mandatory and was then 50 Gy to PTV1 10 Gy to PTV2: 25 fractions to PTV1 5 fractions to PTV2: Central/infield 80.9% Marginal 5.7% Distant 13.3%: Median survival 14.2 mo Median time to recurrence 7.5 mo 1-y OS 66% 1-y PFS 30%: Chang Glioblastoma is a fatal illness progressive disease was defined as a new lesion or an increase by 25% or more 70 to 85) to either postoperative radiotherapy (50.4 Gy in 28 fractions) randomised patients between 60 Gy in 30 fractions versus 45 Gy in 20 fractions found that the survival HR was 1.0 (95% CI, 0.54–1.89)16, suggesting that a shorter course of radiation may be appropriate for this cohort of patients. More recently, the NOA-08 study17 randomised 412 patients to standard radiation alone of 60 Gy in 30 fractions Search Results Short Course Chemo-Radiation Therapy for Patients With Newly Diagnosed Glioblastoma Study Purpose This is a prospective, randomized, open-label, exploratory trial of temozolomide-based chemo-radiotherapy which compares two widely used established radiation schedules with either 40 Gy in 15 fractions or 25 Gy in 5 fractions with concurrent temozolomide for both schedules in Scoccianti et al.
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6 Jun 2019 Forty, fourty-five, and fifty grays in 15 fractions were prescribed to 95% of Glioblastoma multiforme (GB) is the most common primary brain tumor. y in 15 fractions and 25 Gy in 5 fractions) without concurrent TMZ i
Better survival has been reported in elderly patients treated with RT compared with those receiving supportive care alone, with similar survival outcome for patients undergoing standard RT (60 Gy over 6 weeks) and hypofractionated RT (25⁻40 Gy in 5⁻15 daily fractions). A phase III trial conducted by Roa and colleagues compared two different hypofractionation schemes (40 G y in 15 fractions and 25 Gy in 5 fractions) without concurrent TMZ in patients ≥ 65 years of age with KPS >50 . No differences in OS, PFS, or quality of life were observed between the two arms. Roa et al. reported no significant survival differences between 40 Gy in 15 fractions and 25 Gy in 5 fractions in the elderly or frail patients with GBM, suggesting that the α/β ratio of GBM could be lower than 2–3 Gy .
Active Comparator: 25 Gy in 5 fractions Patients randomized to 25 Gy in 5 fractions will receive 150 mg/m^2 temozolomide per day for 5 days starting the first day of radiotherapy. This treatment will be followed by standard monthly 5 day cycles at 150 mg/m^2 for upto 1 year.
2017-12-01 Recently, in a phase I dose-escalation study, Chen and co-workers demonstrated that 60 Gy can be delivered with IMRT in 6-Gy fractions within 2 weeks (BED for glioblastoma multiforme, 119.4 Gy; equivalent dose in 2 Gy per fraction-EQD2-for normal brain, 108.9 Gy) with concurrent and adjuvant TMZ without unacceptable acute toxicity [22].In our previous study it has been shown that accelerated 2019-09-21 Reirradiation of glioblastoma through the use of a Reduced dose Rate on a tomotherapy unit www.tcrt.org Pulsed Reduced Dose Rate (standard 2 Gy fraction, 2 Gy in ten 0.2 Gy fractions without gridblocking, two grid HR = 1.82 with a 95% CI ranging from 1.25 to 3.10). These data compare favor- A short-course RT regimen of 25 Gy in 5 fractions is an acceptable treatment option for patients aged ≥65 years, mainly those with a poor performance status or contraindication to chemotherapy, which would be indicated in cases of methylated O6 methylguanine-DNA-methyltransferase promoter tumors. Active Comparator: 25 Gy in 5 fractions Patients randomized to 25 Gy in 5 fractions will receive 150 mg/m^2 temozolomide per day for 5 days starting the first day of radiotherapy. This treatment will be followed by standard monthly 5 day cycles at 150 mg/m^2 for upto 1 year. 2017-07-15 · Following this tendency, the IAEA proposed a randomized trial comparing 25 Gy in 5 fractions over a period of 1 week versus 40 Gy in 15 fractions over a period of 3 weeks .
Age ≥ 70. WHO 0‐2. RT (60 Gy/30 fractions ing tumor with a 1.5 cm margin. An isotropic expansion of 3 mm was added to the CTV 50 and CTV 60 to generate the planning target volume (PTV) 50 and PTV 60 respectively. A total dose of 60 Gy was delivered at 2 Gy per fraction (50 Gy in 25 fractions to CTV 50 followed by a boost of 10 Gy in 5 fractions to CTV 60) was delivered in the CRT arm.